CLINICAL COVID-19 CONVALESCENT PLASMA RESEARCH

All articles and educational materials are provided as a courtesy to the medical community and should not be construed as an endorsement by MITRE of this Information. MITRE cannot attest to the accuracy of the Information provided by these External Sites. By utilizing the resources on this page, you hereby acknowledge that you have read and understand the Terms of Use as it pertains to such External Sites and Information.

Preprints: Preprints contain research findings that have yet to be certified by the scientific community and published in a medical journal. Since the certification process can be lengthy, authors choose to publish their findings early to facilitate discussions, commentary, and further research by other medical professionals. These articles and the Information therein are provided “AS IS” and may be altered during the peer review process.

Peer Reviewed Articles: Articles have completed the peer review process and have been published in medical journals. Please note, some External Sites that host medical journals may require membership to access full article content.

Mortality rates in matched cohort, pseudo-randomised and randomised trials of convalescent plasma given to COVID-19 patients

11/20/2020 | medRxiv

This meta-analysis of 17 studies with a total of 2,378 CCP treated patients showed that overall mortality reduction benefit for CCP treated hospitalized patients was statistically significant.
Evidence favoring the efficacy of convalescent plasma for COVID-19 therapy

10/29/2020 | medRxiv

This meta-analysis of observational and RCTs of use of CCP for hospitalized from across the world concludes that CCP patients exhibited a lower mortality rate compared to patients receiving standard treatment.
Development of a Rapid Point-Of-Care Test that Measures Neutralizing Antibodies to SARS-CoV-2

12/16/2020 | medRxiv

This paper details the development of a portable, inexpensive, reliable, and rapid neutralizing antibody assay that could have future use in assessing COVID-19 vaccine immunity.
Convalescent Plasma for COVID-19. A randomized clinical trial

7/3/20 | medRxiv

Most COVID-19 patients already have high neutralizing antibody titers at hospital admission. Screening for antibodies and prioritizing convalescent plasma to risk groups with recent symptom onset will be key to identify patients that may benefit from convalescent plasma.
The therapeutic effectiveness of Convalescent plasma therapy on treating COVID-19 patients residing in respiratory care units in hospitals in Baghdad, Iraq

6/30/20 | medRxiv

Patients received convalescent plasma showed reduced duration of infection in about 4 days, and showed less death rate, 1/21 versus 8/28 in control group.

Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19

1/13/2021 | New England Journal of Medicine

For hospitalized COVID-19 patients not requiring mechanical ventilation, this study found that transfusion of plasma with higher anti–SARS-CoV-2 IgG antibody levels was associated with a lower risk of death than transfusion of plasma with lower antibody levels.
Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults

1/7/2021 | New England Journal of Medicine

In this randomized controlled trial, older adults who received high titer plasma within three days of COVID-19 symptoms were about 50% less likely to progress to severe respiratory disease.
Robust neutralizing antibodies to SARS-CoV-2 infection persist for months

12/24/2020 | Science

COVID-19 survivors of mild to moderate cases were found to have neutralizing antibody titers persisted for at least 5 months after infection, which suggest that the chance of reinfection may be lower than is currently feared.
A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia

11/24/2020 | New England Journal of Medicine

This randomized trial underscores findings that in patients who are already severely ill with pneumonia, CCP does not provide a mortality benefit. (Argentina: PlasmAR study group)
Significantly decreased mortality in a large cohort of COVID-19 patients transfused early with convalescent plasma containing high titer anti-SARS-CoV-2 spike protein IgG

11/4/2020 | National Institutes of Health

Researchers from Houston Methodist Hospital compared 351 patients who received CCP with retrospective propensity matched controls, finding that high-titer CCP delivered soon after hospitalization significantly reduces mortality.
Convalescent plasma treatment of severe COVID-19: a propensity score–matched control study

9/15/2020 | Nature Medicine

This U.S. study of patients early in the pandemic identifies "high titer" CCP as the most potentially effective against COVID-19.
Mortality reduction in 46 severe Covid-19 patients treated with hyperimmune plasma

12/1/2020 | Haematologica

Hyperimmune plasma in Covid-19 shows promising benefits, to be confirmed in a randomized controlled trial.
Serological Analysis of New York City COVID-19 Convalescent Plasma Donors

11/18/2020 | Journal of Clinical Microbiology

This study determined the effectiveness of several commercially available SARS-CoV-2 antibody level tests, showing that a large proportion of convalescent plasma samples have modest antibody levels and that commercially available tests have various degrees of accuracy in predicting antibody levels.
Hospitalized COVID-19 patients treated with Convalescent Plasma in a mid-size city in the midwest

10/12/2020 | Translational Medicine Communications

Results demonstrate that convalescent plasma is associated with reducing ventilatory requirements in patients with both severe and life-threatening disease, but appears to be most beneficial when administered early in the course of disease when patients meet the criteria for severe illness.
Convalescent plasma treatment of severe COVID-19: A matched control study

9/15/2020 | Nature Medicine

Outcomes of 39 hospitalized patients with severe to life-threatening COVID-19 who received convalescent plasma transfusion were compared against a cohort of retrospectively matched controls, concluding convalescent plasma transfusion is a potentially efficacious treatment option; data suggest that non-intubated patients may benefit more than those requiring mechanical ventilation.
Use of Convalescent Plasma in Hospitalized Patients With COVID-19 - Case Series

8/6/20 | American Society of Hematology

Study comprised of 20 COVID-19 patients receiving Convalescent Plasma (CP) suggests CP use in severe and critically ill patients with COVID-19 may improve survival if given early in in the course of disease.
Treatment of Coronavirus Disease 2019 (COVID-19) Patients with Convalescent Plasma

8/1/2020 | Science Direct

Outcomes from this case series of 25 patients indicate that administration of convalescent plasma is a safe treatment option for those with severe COVID-19 disease.
Early Safety Indicators of COVID-19 Convalescent Plasma in 5,000 Patients

6/11/20 | Journal of Clinical Investigation

COVID-19 patients transfused with convalescent plasma provides no signal of toxicity beyond what is expected from plasma use in severely ill patients.
A Randomized Trial of Convalescent Plasma for COVID-19—Potentially Hopeful Signals

6/3/20 | JAMA

The first RCT of CCP, from China, showed no statistically significant benefit in clinical improvement at 28 days but does suggest that high titer antibody may have antiviral efficacy.
Effectiveness of convalescent plasma therapy in severe COVID-19 patients

4/28/20 | National Academy of Sciences

To confirm safety of convalescent plasma (CP) transfusion and its effectiveness as a COVID-19 treatment, 10 adults with confirmed COVID-19 were given one dose of 200 mL of CP derived from recently recovered donors as part of an overall supportive care regimen. Several clinical factors improved post CP transfusion.
Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma

3/27/20 | JAMA

Five critically ill patients with COVID-19 and acute respiratory distress syndrome (ARDS) were administered convalescent plasma containing neutralizing antibody, which resulted in an improvement in clinical status. (China)

Press Releases

Suggested Criteria for Selecting Best CCP Donors

10/19/2020 | Johns Hopkins Bloomberg School of Public Health

New data collected in this study suggest sex, age, and severity of disease may be useful in identifying COVID-19 survivors who are likely to have high levels of antibodies.
Emergency Use Authorization for CCP

8/23/20 | FDA

As of Aug 23, the FDA has issued an Emergency Use Authorization (EUA) to permit the emergency use of COVID-19 convalescent plasma (CCP) for some hospitalized patients. To learn more, please refer to the FDA’s Fact Sheet for Health Care Providers and Fact Sheet for Patients and Parents/Caregivers.
Mayo Clinic launches neutralizing antibody test to advance COVID-19 therapies

6/11/20 | Mayo Clinic

Mayo Clinic has created and launched a new SARS-CoV-2 neutralizing antibody test, which measures a subset of antibodies able to independently inactivate the COVID-19 virus and potentially prevent re-infection. This new test indicates how effective a potential Convalescent Plasma (CP) donor’s antibodies are at neutralizing the virus.

Education

ASU COVID-19 Diagnostic Commons Website

1/7/2021 | ASU College of Health Solutions

Dr. Mara G. Apinsall of Arizona State University (ASU) gave a presentation on ASU College of Health Solutions' COVID-19 Diagnostics Commons website. This website provides up-to-the-minute data related to COVID-19 diagnostic testing in hopes of helping governments make better decisions about when and how to open their economics up.
Clarifying the Emergency Use Authorization Framework for COVID-19 Convalescent Plasma: Considerations for Clinicians

11/18/2020 | Infectious Diseases Society of America and AABB

Joint document by American Assoc. of Blood Banks and the Infectious Disease Society of America indicating that patients who received CCP available evidence indicates that the best outcomes are likely to occur in those who receive a high-titer unit of CCP within 3 days of COVID-19 diagnosis or admission to the hospital.
Convalescent Plasma and Immune Therapies for COVID-19

9/16/2020 | COVID-19 Healthcare Coalition Response

Researchers and clinicians are working hard to develop immune therapies to treat COVID-19—including the use of convalescent plasma and hyperimmune globulin. Dr. Mark McClellan et al. discuss the current studies regarding convalescent plasma effectiveness; Dr. Nigel Paneth discusses the current studies regarding convalescent plasma effectiveness; and Dr. William Mezzanotte discusses the current state of using Hyperimmune Globulin (H-IG) as a potential treatment.
Update on Convalescent Plasma in COVID-19

5/27/20 | Philippe R. Bauer, MD, PhD

This is a presentation provides an overview of the findings presented in a preprint titled Early Safety Indicators of COVID-19 Convalescent Plasma in 5,000 Patients (5/14/2020 MedRxIV) that Dr Bauer co-authored. Note that this article has since been peer reviewed and included in the Journal of Clinical Investigation, dated 6/11/2020.
Deployment of convalescent plasma for the prevention and treatment of COVID-19

4/7/20 | The Journal of Clinical Investigation

This article acts as a guidebook for the healthcare system to use in scaling up Convalescent Plasma availability as a COVID-19 treatment.

THE FIGHT IS IN US

CLINICAL COVID-19 CONVALESCENT PLASMA RESEARCH

PREPRINTS

PREPRINTS

PEER REVIEWED ARTICLES

PEER REVIEWED ARTICLES

ADDITIONAL RESOURCES

ADDITIONAL RESOURCES

Press Releases

Education

Research Repositories